Explore the Future of Biomanufacturing
Welcome to my blog! I'm James, a strategic advisor and coach with over 20 years of experience in biotech and executive leadership. I've built high-performing teams and led groundbreaking research in stem cell metabolism, regenerative medicine, and cultured meat. As a passionate advocate for biomanufacturing's world-changing potential, I'm excited to share my knowledge and ideas with you.
What You’ll Discover Here
🔬 Latest Innovations: Explore cutting-edge advancements in biomanufacturing, cultivated meat, and cellular agriculture.
🚀 Founder's Corner: Access valuable tools and insights developed for my coaching program, tailored specifically for technical founders.
🎙️ Industry Voices: Every two weeks, enjoy an in-depth interview with a founder, investor, or operator in the biomanufacturing space.
🚀"What We Do in Life Echoes in Eternity"
… And similarly, how you treat your cells during isolation and expansion impacts your final yield (apologies to Russell Crowe, both for the quote and the image 😂).
🎙️Fogponics, molecular farming and my chat with the Lite & Fog crew
Recently, I had the pleasure of discussing this molecular farming with Uwe Peter and Martin Peter from Lite&Fog. They're pioneering the use of fogponics to enhance the efficiency and yield of molecularly farmed products.
🚀Unlocking the Potential of Compound Libraries for Biomanufacturing Optimization
In biomanufacturing, developing and optimizing cell culture media formulations is crucial. This step is vital for maximizing yields—whether it's proteins, RNA, monoclonal antibodies, or total biomass—and minimizing costs. Despite its importance, media optimization remains a resource-intensive and time-consuming endeavor.
🎙️ Microfluidics for large scale cell harvesting?
Traditionally, centrifugation, whether continuous or batch, has been the go-to solution. But, as we aim for higher volumes, striking a balance between efficiency, speed, and cell integrity becomes a significant challenge 🔄. This is where innovative approaches like microfluidics might come into play.
🍖Class-specific growth factors for cultured seafood?
In an industry where cost reduction and yield maximization are critical for commercial viability 💰📈, the need for species- or class-specific growth factors will likely become evident. This need is particularly acute in the context of crustacean cell culture, which generally shows poor responsiveness to mammalian serum. 🦐
🚀Unique applications of biomanufacturing
Micro-algae skis remain a standout innovation for me. What's the most extraordinary bio-based product you've encountered / are working-on?
🚀My Learnings on the Importance of Cryopreservation in Biomanufacturing
When it comes to the freezing and thawing of cells, the challenges of viability, the toxicity of freezing agents, and scaling up cryopreservation can significantly influence the Cost of Goods Sold (COGS) in biomanufacturing.
🚀Unlocking Potential: Exosomes & Cultured Meat Synergy 🌱🔬
The commercial scale production of cultured meat will lead to an intriguing by-product: spent media. This medium, though (somewhat) nutrient-depleted and filled with waste, harbors a treasure trove of extracellular vesicles known as exosomes. Packed with proteins, lipids, and RNA, these tiny powerhouses have vast potential in a myriad of applications, including the therapeutic and broader biomanufacturing spaces.
🍖From One-at-a-Time to Automation and Data Modelling in Media Optimisation 🔄
With the cell and gene therapy industry shifting more towards Industry 4.0, focusing on automation, large-scale data analysis and modelling, and AI, I imagine we're going to see an increasing number of third-party solutions to the media design problem. This should have the flow-on effects of increasing yield and reducing costs - for therapies, for food and for any product developed using biomanufacturing 🌐.
🚀Navigating the "Holy Trinity" of Biomanufacturing
In my four-year journey through the biomanufacturing landscape, (primarily focussed on applications for cultured meat), a recurring theme has emerged: the success of any biomanufacturing process hinges on a harmonious blend of the right cell line 🧬, the perfect media formulation 🧪, and a finely tuned bioprocess 🔄.
🚀Federal investment in Australian R&D is on fire (in the bad way)
Australia is home to some of the world's most exceptional research, medical and otherwise. Yet, we can’t afford to relegate R&D investment to an afterthought or a 'nice to have.' The lack of real investment will have far-reaching economic and societal impacts.
🚀 Maximizing Bioprocessing Potential with Advanced Data Management Systems 🌱
With biotech evolving towards Industry 4.0, embracing principles like interoperability and modularity, several companies have stepped up. They offer innovative control, data management, and analysis software solutions, ranging from specialized data management tools to all-in-one integrated systems. 🌐🤖
🚀Decoding Cell Culture Media: Paving the Way for Efficacious, Consistent, Safe and Ethical Biotech Practices
The biotech landscape is rapidly evolving, and the media we choose for cell cultivation is more critical than ever. From ethical food production to life-saving cell therapies, these decisions affect us all. I'm looking to connect with thought leaders and innovators who are navigating this space.
🚀Is 2024 the year of the cellular and bioprocessing revolution? 🌱💡
As AI captures headlines, a quiet revolution unfolds in cellular bioprocessing. This revolution is poised to introduce new foods, clothes, therapies, and unimaginable products into our lives. 🚀✨