Explore the Future of Biomanufacturing

Welcome to my blog! I'm James, a strategic advisor and coach with over 20 years of experience in biotech and executive leadership. I've built high-performing teams and led groundbreaking research in stem cell metabolism, regenerative medicine, and cultured meat. As a passionate advocate for biomanufacturing's world-changing potential, I'm excited to share my knowledge and ideas with you.

What Youโ€™ll Discover Here

๐Ÿ”ฌ Latest Innovations: Explore cutting-edge advancements in biomanufacturing, cultivated meat, and cellular agriculture.
๐Ÿš€ Founder's Corner: Access valuable tools and insights developed for my coaching program, tailored specifically for technical founders.
๐ŸŽ™๏ธ Industry Voices: Every two weeks, enjoy an in-depth interview with a founder, investor, or operator in the biomanufacturing space.

๐ŸŽ™๏ธ Curing salami, treating hair loss and growing cultivated meat
Industry Voices James Ryall Industry Voices James Ryall

๐ŸŽ™๏ธ Curing salami, treating hair loss and growing cultivated meat

This week, I had the pleasure of speaking with Ethan Hunter, co-founder and COO of the South African-based precision fermentation startup, Immobazyme. Awkward Mission Impossible jokes aside (on my end), it was a fascinating conversation about the unique and diverse approach he and his co-founders have taken to building a B2B biomanufacturing company. One of the standout aspects of Immobazymeโ€™s journey is the sheer breadth of markets they operate inโ€”ranging from cultivated meat to salami to hair loss treatments!

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๐ŸŽ™๏ธ From Glow-in-the-Dark Carrots to Venture Capital
Industry Voices James Ryall Industry Voices James Ryall

๐ŸŽ™๏ธ From Glow-in-the-Dark Carrots to Venture Capital

For this weekโ€™s newsletter, I had the opportunity to chat with Eshan Samaranayake from Better Bite Ventures and author of the Better Bioeconomy newsletter. This feels like a full-circle moment for me, as Eshan interviewed me shortly after I left Vow in early 2024. Our friendship is a great example of the power of networkingโ€”and LinkedIn in particular.

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๐ŸŽ™๏ธ What does minestrone soup and biomanufacturing have in common?
Industry Voices James Ryall Industry Voices James Ryall

๐ŸŽ™๏ธ What does minestrone soup and biomanufacturing have in common?

This metaphor perfectly captures one of the biggest challenges in biomanufacturing today: waste and side-stream valorization. Itโ€™s also one of the first things Jason Whitfield, an investment associate at Main Sequence VC, shared with me during our initial conversation. From the get-go, we dived into biomanufacturing opportunities in Australia, and Jasonโ€™s ability to clearly articulate complex challenges like this one was striking.

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๐ŸŽ™๏ธ How an Octopus can Accelerate your Bioprocess - An interview with Cristofer Rybner of Reocto

๐ŸŽ™๏ธ How an Octopus can Accelerate your Bioprocess - An interview with Cristofer Rybner of Reocto

For biomanufacturing to have the global impact weโ€™re all hoping for, many things will need to change. Biomanufactured products like food and textiles, while starting in the luxury space, must eventually come down in price to become widely accessible. This will require changes to the underlying technologies. One critical piece of infrastructure is the bioreactorโ€”where cells or organisms are grown at a massive scale ๐ŸŒฑ.

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๐ŸŽ™๏ธ Sausages for Science
Industry Voices James Ryall Industry Voices James Ryall

๐ŸŽ™๏ธ Sausages for Science

I had the pleasure of chatting with two incredible founders who've been building a vibrant scientific community right here in Melbourne. Samuel Wines and Andrew Gray, co-founders of the shared co-working lab space CoLabs, shared their fascinating backgrounds, what drives them, and their vision for the future.

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๐ŸŽ™๏ธ Cockroaches versus Unicorns?
Industry Voices James Ryall Industry Voices James Ryall

๐ŸŽ™๏ธ Cockroaches versus Unicorns?

"We have a lot of companies building real, tangible solutions. Incumbents are being squeezed by new regulations and advances in technology, creating a perfect storm for innovation. ๐ŸŒช๏ธ Build something real, co-develop with customers, and start generating revenue quickly. Everyoneโ€™s hunting for unicorns. Iโ€™m more interested in cockroachesโ€”companies that can grow and be strong regardless of the market. You canโ€™t kill them!"

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๐ŸŽ™๏ธ Schrรถdingerโ€™s Egg - Here, but Not (from) Here ๐Ÿฅ”

๐ŸŽ™๏ธ Schrรถdingerโ€™s Egg - Here, but Not (from) Here ๐Ÿฅ”

Founded in 2022, and funded by several VCโ€™s (led by FoodLabs) PoLoPo is now growing ovalbumin-loaded potatoes in growth rooms in Israel. Ovalbumin is their first productโ€”a protein used in a surprisingly large percentage of food productsโ€”but their vision extends much further. They plan to develop the potato as a manufacturing platform for dozens (eventually hundreds) of ingredients. Turning the humble potato into one of the worlds most advanced manufacturing facilities. ๐Ÿญ

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๐ŸŽ™๏ธ Microfluidics for large scale cell harvesting?

๐ŸŽ™๏ธ Microfluidics for large scale cell harvesting?

Traditionally, centrifugation, whether continuous or batch, has been the go-to solution. But, as we aim for higher volumes, striking a balance between efficiency, speed, and cell integrity becomes a significant challenge ๐Ÿ”„. This is where innovative approaches like microfluidics might come into play.

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